Glossary · Molecule

Ambroxan

Ambroxan (also marketed as Ambrox and Cetalox; CAS 6790-58-5) is a synthetic terpenoid derived from ambrein, the key olfactive compound of natural ambergris, and delivers a warm, woody, slightly marine amber quality that amplifies skin-on-skin diffusion; it has become one of the most widely used base molecules in contemporary fine fragrance (Firmenich documentation, accessed 2026-05-27).

Technical detail

Ambroxan is produced by synthesis from sclareol (derived from clary sage) or from labd-13-en-8α,15-diol. It exists in two enantiomers; the (,)-enantiomer (the natural form) has the strongest olfactive potency. Commercial ambroxan is typically a racemic or enriched mixture depending on the manufacturer (Perfumer & Flavorist, accessed 2026-05-27).

Its most distinctive property is skin magnification: ambroxan binds to receptors in skin cells and amplifies the wearer's natural skin warmth, creating a second-skin, intimate diffusion effect rather than loud projection. At low doses (0.1, 0.5%) it functions as a sophisticated base modifier; at high doses (5, 15%+) it becomes the dominant olfactive statement, as in Molecule 02 (Escentric Molecules) or Baccarat Rouge 540 (Maison Francis Kurkdjian, co-starring ethyl maltol) (Fragrantica, accessed 2026-05-27).

Examples

  • Molecule 02 (Escentric Molecules, 2008, Geza Schoen): ambroxan as the sole olfactive statement; the purest illustration of its skin-amplifying property.
  • Baccarat Rouge 540 (Maison Francis Kurkdjian, 2015, Francis Kurkdjian): ambroxan and ethyl maltol create the signature warm, luminous amber-floral.
  • Santal 33 (Le Labo, 2011, Frank Voelkl): ambroxan contributes the warm, dry woody foundation.

Sources

Published 2026-05-27 · Updated 2026-05-27 · Last fact check: 2026-05-27 · Osmetheca